She’s retiring, after four decades.
Among other things, this is significant for space policy. She’s been a strong supporter of NASA over that period (particularly, of course, Goddard Space Flight Center in her home state), and of Wallops. Whoever replaces her as the next Senator from Maryland will probably be as supportive, but will have much less clout, at least initially.
Unfortunately, she will still be around long enough to ensure continuation of the JWST mess.
Also, one of the people said to be interested in her seat is Rep. Donna Edwards, who would be just as bad if not worse.
Yes, but she wouldn’t be chair, or even ranking member, of the appropriations committee.