I was going to comment on this strange and hyperbolic broadside at the Shuttle, and the manned space program in general from John Derbyshire, but Mark Whittington (who really should spell check his posts) and Clark Lindsey have preempted much of what I would have written.
Briefly, while I agree with his conclusions, he gets there by accident, because his premises are mostly wrong, and his numbers exaggerated beyond any semblance of reality.