Paul Dietz points out (in comments) that if Frances hits the cape as a Cat 4 or greater, none of the major facilities are designed to take it. If the VAB, OPF and LC-39 are significantly damaged, it could mean that the Shuttle will retire even sooner than the current plan (i.e., it will never fly again). It would be a strange end to the current trajectory of our four-plus-decade manned space program, but it might be an opportunity for a clean start, since there won’t be an opportunity for a rear-guard action to save the Shuttle (and it may even finally put to rest notions of Shuttle derivatives, though that’s probably asking too much).

[Update a few minutes later]

As Paul mentions, he found the info at the new and improved NASA Watch, now with an infinite percent more permalinks.